Table: Nolla vs Common Antimicrobials

Minimum inhibitory concentration (MIC) of various antimicrobials vs. Nolla silver polymer technology against S. aureus under varying exposure times.

  • Nolla’s results shown below against S. aureus are comparable to Nolla’s results against MRSA.
  • Nolla inhibits S. aureus significantly faster than silver nitrate and does so with low silver concentrations.
  • The performance data below shows a striking difference between alcohol-free hand sanitizers based on Nolla and Triclosan. While Nolla-based hand sanitizer’s silver concentration is only 90 mg/L, Triclosan concentration in hand sanitizers is most often between 10,000 to 20,000 mg/L.

 

SubstanceConcentration (mg/L) S. Aureus reduction and exposure time 
Nolla¹990.0% in 5 minutes
Nolla¹9098.7% in 5 minutes
Nolla¹150>99.99% in 60 seconds
Nolla¹

150>99.99999% in 5 minutes
Triclosan (2,4,4′-trichloro-2′-hydroxydiphenyl ether)0.5 – 1.099.9% in 24 hours
Triclosan (2,4,4′-trichloro-2′-hydroxydiphenyl ether)0.2590.0% in 24 hours
Quaternary ammonium compounds (QACs)²5999.99% in 24 hours
Chlorhexidine digluconate²7199.99% in 24 hours
Glutaraldehyde²187599.99% in 24 hours
Formaldehyde²15699.99% in 24 hours
Ethanol²8750099.99% in 24 hours
PVPI, Povidone-iodine²625099.99% in 24 hours
Chlorine-releasing-agents²
(CRAs) pH>9
94599.99% in 24 hours
H2O2²93899.99% in 24 hours
Nano silver particles¹12599.99% in 24 hours
Silver sulfadiazine¹1990.0% in 24 hours
Silver nitrate¹1090.0% in 24 hours
Silver dihydrogencitrate¹227099.9% in 24 hours


¹ Silver concentration in the compound
² Mazzola P, Jozala A, de Lencastre Novaes L, Moriel P, Penna T. Minimal inhibitory concentration (MIC) determination of disinfectant and/or sterilizing agents. Braz. J. Pharm. Sci. 2009;45(2):241-248. http://www.scielo.br/pdf/bjps/v45n2/v45n2a08