Nolla kills multidrug-resistant E. Coli with just 1.5 ppm of silver

Water-based Nolla Polymer eliminates E. Coli strain resistant against 36 widely-used antimicrobials.

Escherichiacoli (E. Coli) are gram negative bacteria. Most of the E. Coli strains are harmless and an important part of healthy human intestinal tract. However, there are some strains of E. Coli that are pathogenic, which can cause serious illnesses. Gram negative bacteria are intrinsically resistant towards many antimicrobials, including both antibiotics and biocides. There, the intrinsic resistance stems largely from the outer membrane, consisting of lipopolysaccharides. Alarmingly, resistance is increasing among gram negative bacteria, threatening the treatment of gram negative bacteria based infections.

Nolla Antimicrobial has developed an antimicrobial technology over the past years to overcome the problems in eradicating highly resistant and dangerous pathogens. Nolla technology is based on ionic silver, which is the most antimicrobial form of silver. An intelligent polymer carrier is used to preserve and deliver silver ions. Nolla technology is a unique concept among antimicrobials, allowing maximization of the antimicrobial efficiency and minimization of the needed amount of active substance, silver (chloride), which enables safe and effective use.

Nolla technology was recently tested against a resistant E. Coli ATCC BAA-2469 strain, which is known to be resistant against 36 widely-used antimicrobials, including carbepenems, β-lactams, cephalosporins, quinolones, tetracyclines, glycylcyclines, aminoglycosides and dihydrofolate reductase inhibitors. Results showed Nolla technology to be bactericidal with just 1.5 ppm of ionic silver (corresponding to 0.02% of Nolla polymer) against the MDR strain of E.Coli, while MIC performance was achieved with only 0.75 ppm of silver. Water was used as the solvent in the measurements, which were carried out by EPA/FDA GLP-compliant Microchem Laboratory (

The results display the tremendous power of Nolla technology against the highly resistant gram negative bacterial strain of E. Coli. The possibility to use water based solutions instead of alcohols provides safety against misuse and comfort in topical applications such as hand sanitizers.

Nolla technology is the most effective water based sanitizer technology available that fulfils the handrub and surface disinfection standards (EN1500 and EN13697).

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